Chronic Arachidonic Acid Administration Decreases Docosahexaenoic Acid- and Eicosapentaenoic Acid-Derived Metabolites in Kidneys of Aged Rats

Chronic Arachidonic Acid Administration Decreases Docosahexaenoic Acid- and Eicosapentaenoic Acid-Derived Metabolites in Kidneys of Aged Rats

Arachidonic acid (ARA) metabolites produced by cyclo-oxygenase and lipoxygenase are important mediators maintaining physiological renal function. However, the effects of exogenous ARA on kidney function in vivo remain unknown. This study examined the effects of long-term oral ARA administration on normal renal function as well as inflammation and oxidative stress in aged rats. In addition, we m...

Evaluating the effect of arachidonic acid and eicosapentaenoic acid on induction of adipogenesis in human adipose-derived stem cells

Objective(s): Adipose tissue is one of the most important endocrine organs that liberates many metabolic mediators such as hormones, cytokines, and chemokines. Different types of fatty acids have key roles in adipogenesis. The aim of this study was to evaluate the effects of two essential fatty acids, including Arachidonic acid (AA) and Eicosapentaenoic acid (EPA), on ...

Reduced ratio of eicosapentaenoic acid and docosahexaenoic acid to arachidonic acid is associated with early onset of acute coronary syndrome

BACKGROUND The hospitalization rate for acute coronary syndrome (ACS) for people aged ≤50 has remained stable over the past decade. Increased serum levels of n-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are associated with a decreased incidence of cardiovascular events and mortality in older patients; however, it is currently unkno...

Hronic Administration of Docosahexaenoic Acid R Eicosapentaenoic Acid, but Not Arachidonic Acid, Lone or in Combination with Uridine, Increases Brain Hosphatide and Synaptic Protein Levels in Gerbils

bstract—Synthesis of phosphatidylcholine, the most abunant brain membrane phosphatide, requires three circulating recursors: choline; a pyrimidine (e.g. uridine); and a polynsaturated fatty acid. Supplementing a choline-containing iet with the uridine source uridine-5=-monophosphate (UMP) r, especially, with UMP plus the omega-3 fatty acid docosaexaenoic acid (given by gavage), produces substan...

Arachidonic Acid Metabolites in Inflammation